Estrategias Actuales para el Tratamiento Quirúrgico del Agujero Macular
Marcelo Zas, Marcos Mendaro, Mariano Cotic, Adriana Nieva, Elio Dilascio, Eugenia Páez Soria, María de los Ángeles Cenoz, Agustina Piczman, Pablo Chiaradía
Citation Information :
Zas M, Mendaro M, Cotic M, Nieva A, Dilascio E, Soria EP, Cenoz MD, Piczman A, Chiaradía P. Estrategias Actuales para el Tratamiento Quirúrgico del Agujero Macular. 2023; 16 (4):27-33.
El agujero macular es un defecto retinal de espesor completo que afecta al centro foveal y produce la pérdida de la agudeza visual central. Numerosos estudios permitieron conocer en mayor profundidad la anatomía e histopatogenia del mismo. La tomografía de coherencia óptica permitió clasificar los agujeros maculares en diferentes estadios y estimar el pronóstico quirúrgico, mediante la medición del diámetro del mismo. En 1991 se propuso para su tratamiento la vitrectomía por pars plana combinada con el desprendimiento de la corteza vítrea posterior y el tamponaje con gas, hasta ese momento se la consideraba una patología prácticamente intratable. Posteriormente se instaló el pelado de la membrana limitante interna como adyuvante de la vitrectomía, incrementando la eficacia del tratamiento. Gracias al avance de la tecnología la tasa de éxito en cuanto al cierre del agujero macular fue aumentando progresivamente. Esta revisión aborda las técnicas que disponemos en la actualidad para el manejo de esta enfermedad e intenta brindar sugerencias para el abordaje quirúrgico en cada caso.
SriniVas R. Sadda, MD. Ryan’s RETINA. Seventh edition. Elsevier; 2022.
Knapp H. Uber isolirte Zerreissungen der Aderhaut in Folge von Traumen auf dem Augapfel. Arch Augenheilkd 1869; 1:6–29.
Gass JD. Idiopathic senile macular hole. Its early stages and pathogenesis. Arch Ophthalmol. 1988 May;106 (5):629-39.
Duker JS, Kaiser PK, Binder S, et al. The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013; 120(12):2611–2619.
Kelly NE, Wendel RT. Vitreous surgery for idiopathic macular hole. Results of a pilot study. Arch. Ophthalmology 1991 May; 108 (5): 654-9.
Eckardt C, Eckardt U, Groos S, et al. Removal of the internal limiting membrane in macular holes. Clinical and morphological findings. Ophthalmologe 1997; 94:545–51.
Duker JS, Kaiser PK, Binder S, et al. The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013;120:2611–9.
la Cour M, Friis J. Macular holes: Classification, epidemiology, natural history and treatment. Acta Ophthalmol Scand 2002;80:579-87.
Liu L, Enkh-Amgalan I, Wang N-K, et al. Results of macular hole surgery. Retina. 2018;38:900–6.
Ch’ng SW, Patton N, Ahmed M, et al. The anchester large macular hole study: is it time to reclassify large macular holes? Am J Ophthalmol. 2018; 195:36–42.
Rezende, F.A., Ferreira, B.G., Rampakakis, E. et al. Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group. Int J Retin Vitr 9, 4 (2023).
Bae K, Kang SW, Kim JH, Kim SJ, Kim JM, Yoon JM. Extent of internal limiting membrane peeling and its impact on macular hole surgery outcomes: a randomized trial. Am J Ophthalmol 2016;169:179-188.
Michalewska Z, Michalewski J, Adelman RA, et al. Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology 2010;117(10):2018–25.
Gu C, Qiu Q. Inverted internal limiting membrane flap technique for large macular holes: a systematic review and single-arm meta-analysis. Graefes Arch Clin Exp Ophthalmol. 2018 Jun;256(6):1041-1049.
Ghassemi F, Khojasteh H, Khodabande A, Dalvin LA, Mazloumi M, Riazi-Esfahani H, et al. Comparison of three different techniques of inverted internal limiting membrane flap in treatment of large idiopathic full-thick-ness macular hole. Clin Ophthalmol 2019; 13:2599-606.
Michalewska Z, Michalewski J, Dulczewska-Cichecka K, Adelman RA, Nawrocki J. Temporal inverted internal limiting membrane flap technique versus classic inverted internal limiting membrane flap technique: A comparative study. Retina 2015;35:1844-50.
Morizane Y, Shiraga F, Kimura S, Hosokawa M, Shiode Y, Kawata T, et al. Autologous transplantation of the internal limiting membrane for refractory macular holes. Am J Ophthalmol 2014; 157:861-90.
Giansanti F, Tartaro R, Caporossi T, Bacherini D, Savastano A, Barca F, Rizzo S. An Internal Limiting Membrane Plug and Gas Endotamponade for Recurrent or Persistent Macular Hole. J Ophthalmol. 2019 Mar 7; 2019:6051724.
Kase S, Saito W, Mori S, Saito M, Ando R, Dong Z, et al. Clinical and histological evaluation of large macular hole surgery using the inverted internal limiting membrane flap technique. Clin Ophthalmol 2017;11:9-14.
Shiode Y, Morizane Y, Matoba R, Hirano M, Doi S, Toshima S, et al. The role of inverted internal limiting membrane flap in macular hole closure. Invest Ophthalmol Vis Sci 2017;58:4847-55.
Rossi T, Trillo C, Ripandelli G. Autologous internal limiting membrane transplant for recurrent idiopathic macular holes [published online ahead of print, 2020 Feb 11]. Eur J Ophthalmol. 2020;1120672120906391. Doi: 10.1177/1120672120906391.
Park SW, Pak KY, Park KH, Kim KH, Byon IS, Lee JE. Perfluoro-n-octane assisted free internal limiting membrane flap technique for recurrent macular hole. Retina 2015;35:2652-6.
Ozdek S, Baskaran P, Karabas L, Neves PP. A modified perfluoro-n-octane-assisted autologous internal limiting membrane transplant for failed macular hole reintervention: A case series. Ophthalmic Surg Lasers Imaging Retina 2017;48:416-20.
Rizzo S, Caporossi T, Tartaro R, Finocchio L, Franco F, Barca F, et al. A human amniotic membrane plug to promote retinal breaks repair and recurrent macular hole closure. Retina 2019;39 Suppl 1: S95-103.
Pacini, B., Bacherini, D., Savastano, A., Rizzo, S. and Caporossi, T. (2022), Comparative analysis of macular microstructure in eyes treated with human amniotic membrane plug or internal limiting membrane transplant for Failed Macular Hole. Acta Ophthalmol, 100: e1031-e1035.
Grewal DS, Mahmoud TH. Autologous neurosensory retinal free flap for closure of refractory myopic macular holes. JAMA Ophthalmol 2016;134:229-30.
Moysidis SN, Koulisis N, Adrean SD, Charles S, Chetty N, Chhablani JK, Cortes JC, Embabi SN, Gordon C, Gregori NZ, Habib A, Hamza H, Hassaan H, Hassan TS, Houghton O, Kadonosono K, Kusaka S, La Mantia A, Lai CC, Lumi X, Maeno T, Mahgoub MM, Mohamed El Baha S, Morales-Cantón V, Nowara M, Okonkwo ON, Parolini B, Rezende FA, Rogalinska I, Rojas S, Steel DH, Stopa M, Wu AL, Yamada K, Yamada M, Mahmoud TH. Autologous Retinal Transplantation for Primary and Refractory Macular Holes and Macular Hole Retinal Detachments: The Global Consortium. Ophthalmology. 2021 May;128(5):672-685.
Tabandeh H. Vascularization and reperfusion of autologous retinal transplant for giant macular holes. JAMA Ophthalmol 2020;138:305-9.
Oliver A, Wojcik E. Macular detachment for treatment of persistent macular hole. Ophthalmic Surg Lasers Imaging 2011; 42:6.
Szigiato AA, Gilani F, Walsh MK, Mandelcorn ED, Muni RH. Induction of macular detachment for the treatment of persistent or recurrent idiopathic macular holes. Retina. 2016 Sep;36(9):1694-8.
Zas M, Lasave AF, Alfano A, Saravia M. Surgical Technique for Approaching Chronic or Persistent Macular Holes: Two Case Reports. Am J Ophthalmol Case Rep. 2020 Apr 9;18: 100692.
Alezzandrini A, Dorrego CI, Cibrán MV, Cortina-Revelli V, Rocco FD, Zas M, Wu L. A 24-month follow-up of refractory macular holes treated with an autologous transplantation of internal limiting membrane versus retina expansion technique. Int J Retina Vitreous. 2021 Oct 2;7(1):57.